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Bioactive properties and clinical safety of a novel milk protein peptide

Kreider, Richard B, Iosia, Mike, Cooke, Matthew, Hudson, Geoffrey, Rasmussen, Chris, Chen, Helen, Mollstedt, Olof and Tsai, Men-Hwei (2011) Bioactive properties and clinical safety of a novel milk protein peptide. Nutrition Journal, 10 (99). pp. 1-8. ISSN 1475-2891

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Abstract

Milk protein fractions and peptides have been shown to have bioactive properties. This preliminary study examined the potential mechanisms of action and clinical safety of novel milk protein peptide (MP). A novel MP mixture inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor 2 (VEGFR2), and insulin receptor (IR) with IC50 of 9.85 μM, 7.7 μM, and 6.18 μM respectively. In vitro, this multi-kinase inhibitor causes apoptosis in HT-29 colon cancer cells, and in a C. elegans worm study, showed a weak but significant increase in lifespan. A six week double-blind, placebocontrolled study involving 73 healthy volunteers demonstrated that the MP mixture is safe to consume orally. All clinical blood markers remained within normal levels and no clinically significant side effects were reported. There was some evidence of improved insulin sensitivity, neutrophil-to-lymphocyte ratio (NLR), and quality of life assessment of role of physical function. These data in combination with the observed in vitro anti-cancer properties warrant further clinical studies to investigate this MP mixture as a potential clinical nutrition intervention for improving the quality of life and clinical outcomes in cancer patients.

Item Type: Article
Uncontrolled Keywords: ResPubID24902, health, cancer, neutrophil lymphocyte ratio, insulin sensitivity, quality of life, anti-hypertensive agents, antimicrobial factors, food intake modifiers, immune regulatory factors, chemotherapy, colorectal cancer, liver metastases
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
Depositing User: VUIR
Date Deposited: 05 Dec 2012 04:35
Last Modified: 10 Sep 2019 06:09
URI: http://vuir.vu.edu.au/id/eprint/10383
DOI: https://doi.org/10.1186/1475-2891-10-99
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Citations in Scopus: 12 - View on Scopus

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