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The molecular pathogenesis of osteosarcoma: A review

Choong, Peter F. M, Broadhead, Matthew L, Clark, Jonathan C. M, Myers, Damian E and Dass, Crispin R (2011) The molecular pathogenesis of osteosarcoma: A review. Sarcoma, 2011. pp. 1-12. ISSN 1357-714X

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Abstract

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management.

Item Type: Article
Uncontrolled Keywords: ResPubID24962, chromosomal syndromes, genetic syndromes, alleles, tumour suppressor genes, transforming growth factor, TGF, transforming growth factor, TGF, growth factor beta proteins, TGF-β, bone morphogenic proteins, BMPs, IGF, insulin-like growth factor, Matrix metalloproteinases, MMPs, tumorigenesis
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
Depositing User: VUIR
Date Deposited: 28 Nov 2012 05:12
Last Modified: 04 Jul 2014 06:39
URI: http://vuir.vu.edu.au/id/eprint/10414
DOI: https://doi.org/10.1155/2011/959248
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Citations in Scopus: 198 - View on Scopus

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