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Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

Alikhan, Maliha A, Jones, Christina, Williams, Timothy, Beckhouse, Anthony, Fletcher, Anne L, Kett, Michelle M, Sakkal, Samy, Samuel, Chrishan S, Ramsay, Rob, Deane, James A, Wells, Christine, Little, Melissa, Hume, David and Ricardo, Sharon D (2011) Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses. American Journal of Pathology, 179 (3). pp. 1243-1256. ISSN 0002-9440

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Abstract

Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.

Item Type: Article
Additional Information:

At head of title: Cell Injury, Repair, Aging, and Apoptosis

Uncontrolled Keywords: ResPubID25070, murine kidney, colony-stimulating factor, CSF, macrophages, postnatal organ growth, renal disease, immune effectors, cell-surface tyrosine kinase receptor, CSF-1R, progenitors, urokinase plasminogen activator, collagen content, ageing
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1199 Other Medical and Health Sciences
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
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Depositing User: VUIR
Date Deposited: 30 Nov 2012 05:31
Last Modified: 10 Feb 2015 05:35
URI: http://vuir.vu.edu.au/id/eprint/10470
DOI: https://doi.org/10.1016/j.ajpath.2011.05.037
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Citations in Scopus: 90 - View on Scopus

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