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Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance?

Eynon, Nir ORCID: 0000-0003-4046-8276, Alves, Alberto Jorge, Yamin, Chen, Sagiv, Moran, Duarte, Jose, Oliveira, Jose, Ayalon, Moshe, Goldhammer, Ehud, Sagiv, Michael and Meckel, Yoav (2009) Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance? International Journal of Sports Medicine, 30 (12). pp. 888-891. ISSN 0172-4622

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Abstract

Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the α -actinin-3 ( ACTN3 ) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their eff ect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype + ACTN3 R allele (P = 0.003 for sprinters vs. controls), and the ACTN3 RR genotype + ACE I allele (P = 0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype + ACE I allele being a sprinter (odds ratio 2.67, 95 % confidence interval 1.45 – 4.93) and of ACE II genotype + ACTN3 R allele being a sprinter (odds ratio 3.57, 95 % confidence interval 1.78 – 7.15) was significantly higher than that in the controls. In conclusion, the above data suggest that ACE ID / ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID / ACTN3 R577X genotype combination is not related to the level of performance.

Item Type: Article
Uncontrolled Keywords: ResPubID25128, genotype frequencies, genetics, top-level athletes
Subjects: FOR Classification > 0604 Genetics
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 02 Nov 2012 03:33
Last Modified: 22 Aug 2019 01:20
URI: http://vuir.vu.edu.au/id/eprint/10492
DOI: https://doi.org/10.1055/s-0029-1238291
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Citations in Scopus: 25 - View on Scopus

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