Research Repository

Do PPARGC1A and PPAR alpha polymorphisms influence sprint or endurance phenotypes?

Eynon, Nir ORCID: 0000-0003-4046-8276, Meckel, Yoav, Sagiv, Moran, Yamin, Chen, Amir, Ruthie, Sagiv, Michael, Goldhammer, Ehud, Duarte, Jose and Oliveira, Jose (2010) Do PPARGC1A and PPAR alpha polymorphisms influence sprint or endurance phenotypes? Scandinavian Journal of Medicine and Science in Sports, 20 (1). e145-e150. ISSN 0905-7188 (print) 1600-0838 (online)

PPARGC1 and PPARa and elite endurance VUIR.pdf - Accepted Version

Download (314kB) | Preview


The aim of this study was to determine their frequency distribution among 155 Israeli athletes (endurance athletes and sprinters) and 240 healthy controls. Results showed that there was a significant difference in PPARGC1A Ser482Gly polymorphism genotype frequencies between endurance athletes and sprinters (P50.005) as well as between endurance athletes and controls (P50.0003). However, the sprinters’ genotype and allele frequencies were similar to that of the control group. A significantly lower proportion of PPARGC1A Ser482 allele (0.25) was noted for the endurance athletes compared with controls (0.43, P50.0001). Endurance athletes showed a trend of a higher yet a not significant proportion of the PPAR alpha GG genotype compared with sprinters (P50.051). As we compared between the subgroups of top-level endurance athletes and top-level sprinters, as well as between those of top-level and national-level endurance athletes, we reached more prominent results. In conclusion, our data indicate that a lower frequency of the Ser482 allele and possibly a higher frequency of the GG genotype are associated with increased endurance performance ability.

Item Type: Article
Uncontrolled Keywords: ResPubID25140, elite athletic performance, mitochondrial biogenesis, single nucleotide polymorphisms, SNPs, genotype frequencies, allele frequencies, genomic DNA, talent identification, aerobic performance, anaerobic performance, metabolism
Subjects: Current > FOR Classification > 0604 Genetics
Current > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 27 Feb 2013 05:35
Last Modified: 22 Aug 2019 01:18
ePrint Statistics: View download statistics for this item
Citations in Scopus: 51 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar