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ACE ID genotype affects blood creatine kinase response to eccentric exercise

Yamin, Chen and Amir, Offer and Sagiv, Moran and Attias, Eric and Meckel, Yoav and Eynon, Nir and Sagiv, Michael and Amir, Ruthie (2007) ACE ID genotype affects blood creatine kinase response to eccentric exercise. Journal of Applied Physiology, 103 (6). pp. 2057-2061. ISSN 8750-7587

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Abstract

Unaccustomed exercise may cause muscle breakdown with marked increase in serum creatine kinase (CK) activity. The skeletal muscle reninangiotensin system (RAS) plays an important role in exercise metabolism and tissue injury. A functional insertion (I)/deletion (D) polymorphism in the angiotensin I-converting enzyme (ACE) gene (rs4646994) has been associated with ACE activity. We hypothesized that ACE ID genotype may contribute to the wide variability in individuals’ CK response to a given exercise. Young individuals performed maximal eccentric contractions of the elbow flexor muscles. Pre- and postexercise CK activity was determined. ACE genotype was significantly associated with postexercise CK increase and peak CK activity. Individuals harboring one or more of the I allele had a greater increase and higher peak CK values than individuals with the DD genotype. This response was dose-dependent. (mean +/- SE U/L: II, 8,882 +/- 2,362; ID, 4,454 +/- 1,105; DD, 2,937 +/- 753, ANOVA, P = 0.02; P = 0.009 for linear trend). Multivariate stepwise regression analysis, which included age, sex, body mass index, and genotype subtypes, revealed that ACE genotype was the most powerful independent determinant of peak CK activity (adjusted odds ratio 1.3, 95% confidence interval 1.03–1.64, P = 0.02).In conclusion, we indicate a positive association of the ACE ID genotype with CK response to strenuous exercise. We suggest that the II genotype imposes increased risk for developing muscle damage, whereas the DD genotype may have protective effects. These findings support the role of local RAS in the regulation of exertional muscle injury.

Item Type: Article
Uncontrolled Keywords: ResPubID25144, genetics, renin-angiotensin system, insertion, deletion
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1106 Human Movement and Sports Science
Depositing User: VUIR
Date Deposited: 24 Oct 2012 05:20
Last Modified: 30 Oct 2012 23:12
URI: http://vuir.vu.edu.au/id/eprint/10508
DOI: 10.​1152/​japplphysiol.​00867.​2007
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Citations in Scopus: 16 - View on Scopus

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