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Long-term effects of imatinib on cognition in chronic myeloid leukaemia

Shiell, Kerrie (2009) Long-term effects of imatinib on cognition in chronic myeloid leukaemia. Other Degree thesis, Victoria University.

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Abstract

Imatinib was successfully introduced into haematology-oncology practice in 2001 and rapidly endorsed as a first line treatment for chronic myeloid leukaemia (CML) in the chronic, accelerated, and blastic phases. The survival advantage demonstrated by this target kinase inhibitor has meant that patients are now treated with this agent on a long-term basis. There is a growing literature on the potential toxic effects of chronic imatinib use (Fruttiger et al., 1999; Grove et al., 2004). A safety sub-study undertaken by the Australasian Leukaemia and Lymphoma Group (ALLG) identified a range of subtle effects consistent with the inhibition of targeted kinases in the immunological, respiratory, endocrine, and reproductive systems (Seymour et al., 2004). To date, there has been no attempt to elucidate possible neuropsychological sequelae of chronic imatinib use. However concerns exist about the potential neurotoxic effects of this agent, given that the inhibition of protein kinase in animal studies has been associated with a range of deleterious consequences, such as impaired learning and memory, and reduced synaptic efficacy (Grove et al., 2004; Moresco et al., 2003). The purpose of the current study was to monitor the neuropsychological function of a group of adult CML patients’ newly prescribed imatinib.

Item Type: Thesis (Other Degree thesis)
Additional Information:

A thesis submitted in partial fulfillment of the requirements of the degree of Doctor of Psychology (Clinical Neuropsychology)

Uncontrolled Keywords: Imatinib, chronic myeloid leukaemia, target kinase inhibitors, cognition
Subjects: RFCD Classification > 320000 Medical and Health Sciences
Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Depositing User: Ms Lyn Wade
Date Deposited: 24 Sep 2009 06:27
Last Modified: 23 May 2013 16:41
URI: http://vuir.vu.edu.au/id/eprint/15199
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