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Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance

Petersen, Aaron C (2007) Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance. PhD thesis, Victoria University.

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Abstract

In skeletal muscle, the Na+,K+-ATPase enzyme regulates trans-membrane Na+ and K+ fluxes during contractions, and therefore also affects muscle excitability and plays an important role in delaying muscle fatigue. Consequently, any modulation of Na+,K+-ATPase content or activity has the potential to affect muscle fatiguability. Thus, this thesis investigated three factors thought to impair or down-regulate the skeletal muscle Na+,K+-ATPase – acute exercise, renal disease and digoxin. The related effects on plasma [K+] during exercise and on muscle performance were also examined. This thesis firstly investigated the acute effects of brief intense exercise on muscle Na+,K+-ATPase content and maximal activity (Study 1). Study 2 investigated the effects of end-stage renal disease on plasma [K+] regulation during exercise; examined the relationship between impaired [K+] regulation and muscle performance, and investigated the effects of endurance training in these patients. Study 3 investigated the impacts of end-stage renal disease and renal transplantation on skeletal muscle Na+,K+-ATPase and its relationship with muscle performance. Finally, Study 4 investigated the effects of chronic digoxin administration on skeletal muscle Na+,K+-ATPase content and maximal activity and on muscle performance in healthy humans.

Item Type: Thesis (PhD thesis)
Uncontrolled Keywords: skeletal muscle, physical exercise, renal disease, digoxin
Subjects: RFCD Classification > 320000 Medical and Health Sciences
Faculty/School/Research Centre/Department > School of Sport and Exercise Science
Depositing User: Bingyan Gu
Date Deposited: 28 Oct 2008 03:40
Last Modified: 23 May 2013 16:40
URI: http://vuir.vu.edu.au/id/eprint/1528
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