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The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans

Medved, Ivan (2005) The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans. PhD thesis, Victoria University of Technology.

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Abstract

The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise.

Item Type: Thesis (PhD thesis)
Uncontrolled Keywords: Exercise, Muscles, Fatigue, antioxidants, glutathione, ion regulation, n-acetylcysteine
Subjects: FOR Classification > 1116 Medical Physiology
Faculty/School/Research Centre/Department > School of Sport and Exercise Science
FOR Classification > 1106 Human Movement and Sports Science
Depositing User: VU Library
Date Deposited: 02 Sep 2010 22:19
Last Modified: 23 May 2013 16:45
URI: http://vuir.vu.edu.au/id/eprint/15641
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