Wilson, Ann (2002) The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects. PhD thesis thesis, Victoria University of Technology.

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Abstract

Maternai peripheral hyperinsulinemia and fetal hyperinsulinism that occurs as a conséquence of the treatment of diabetic pregnancy hâve been associated with both gross and microscopic, cellular changes. Thèse include an apparent hyperplacentation and fetal macrosomia and trophoblastic morphofunctional pathology, which may contribute to increased morbidity and mortality rates. Reports hâve indicated that fetal and placental macrosomia does not always resuit from maternai hyperglycemia and that insulin m a y stimulate cellular prolifération in vitro. A family of growth factors known as the Insulin-like Growth Factors (IGFs) hâve been identified and shown to share insulin's biological activities. Thèse, too, are thought to play an important rôle in the growth and development of the fétus. Due to the structural similarities, insulin and the IGFs m a y bind with each other's receptors to elicit a response. The aim of this study was to investigate and compare the effects of insulin and the IGFs on the prolifération and differentiation of cells isolated from the human placenta.

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