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Leptin Stimulation of COXIV is Impaired in Obese Skeletal Muscle Myotubes

McAinch, Andrew and Steinberg, G. R and Mollica, Janelle and O'Brien, Paul E and Dixon, J. B and Kemp, Bruce E and Cameron-Smith, David (2007) Leptin Stimulation of COXIV is Impaired in Obese Skeletal Muscle Myotubes. Obesity Research and Clinical Practice, 1 (1). pp. 53-60. ISSN 1871-403X

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Abstract

The principle finding of this study is the further demonstration of the metabolic inflexibility of skeletal muscle myotubes developed from morbidly obese individuals. It was demonstrated that the acute exposure of cultured skeletal muscle myotubes derived from obese individuals to leptin failed to alter the expression of several key lipid oxidative and mitochondrial genes. Contrary to the obese derived myotubes, cells derived from lean and healthy controls demonstrated a capacity to increase the expression of several key genes. Further analysis is required to elucidate the mechanisms involved, with studies needed to examine leptin-receptor mediated events.

Item Type: Article
Uncontrolled Keywords: ResPubID14436, human obesity, leptin resistance, mRNA, fat metabolism, PDK4, skeletal muscle, fatty acid oxidation and mitochondrial biogenesis, cultured skeletal muscle myotubes, mitochondrial gene
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1103 Clinical Sciences
Depositing User: Yimin Zeng
Date Deposited: 08 May 2013 04:41
Last Modified: 15 Jan 2015 23:13
URI: http://vuir.vu.edu.au/id/eprint/21495
DOI: 10.1016/j.orcp.2006.10.003
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Citations in Scopus: 3 - View on Scopus

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