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The expression of receptors for endocannabinoids in human and rodent skeletal muscle

Cavuoto, Paul, McAinch, Andrew, Hatzinikolas, George, Janovska, Alena, Game, Philip and Wittert, Gary (2007) The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and Biophysical Research Communications, 364 (1). pp. 105-110. ISSN 0006-291X

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Abstract

In this study, have demonstrated the expression of CB2 and TRPV1 in human and rodent skeletal muscle as potential receptor sites for the previously observed effects of AEA [19]. Drugs targeting CB1, CB2, FAAH and TRPV1 for the treatment of obesity, pain and inflammation are currently under development [26,42–44]. The expression of CB2, FAAH and TRPV1 along with CB1 in human and rodent skeletal muscle istherefore an important consideration in the development of these therapeutic targets. Endocannabinoids may have a complex role in skeletal muscle biology.

Item Type: Article
Uncontrolled Keywords: ResPubID14439, endocannabinoids, skeletal muscle biology, lipid derived signalling system, fatty acid amide hydrolase, FAAH, transient receptor potential channel-vanilloid sub-family member 1, TRPV1, cannabinoid receptor type 1, CB1, cannabinoid receptor type 2, CB2, reverse transcription polymerase chain reaction, RT-PCR
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1103 Clinical Sciences
Depositing User: Yimin Zeng
Date Deposited: 06 May 2013 06:29
Last Modified: 15 Dec 2014 22:35
URI: http://vuir.vu.edu.au/id/eprint/21498
DOI: https://doi.org/10.1016/j.bbrc.2007.09.099
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Citations in Scopus: 104 - View on Scopus

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