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The therapeutic potential of GPR43: a novel role in modulating metabolic health

Cornall, Lauren, Mathai, Michael ORCID: 0000-0001-8783-2122, Hryciw, Deanne H and McAinch, Andrew ORCID: 0000-0002-8762-4865 (2013) The therapeutic potential of GPR43: a novel role in modulating metabolic health. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-9071

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Abstract

GPR43 is a receptor for short-chain fatty acids. Preliminary data suggest a putative role for GPR43 in regulating systemic health via processes including inflammation, carcinogenesis, gastrointestinal function, and adipogenesis. GPR43 is involved in secretion of gastrointestinal peptides, which regulate appetite and gastrointestinal motility. This suggests GPR43 may have a role in weight control. Moreover, GPR43 regulates plasma lipid profile and inflammatory processes, which further indicates that GPR43 could have the ability to modulate the etiology and pathogenesis of metabolic diseases such as obesity, type 2 diabetes mellitus, and cardiovascular disease. This review summarizes the current evidence regarding the ability of GPR43 to mediate both systemic and tissue specific functions and how GPR43 may be modulated in the treatment of metabolic disease.

Item Type: Article
Uncontrolled Keywords: G-protein-coupled receptor, GPCR, type 2 diabetes mellitus, T2DM, dietary lipid intake, high-fat diet, obesity, gut microbiota, intestinal digestion, gastrointestinal peptides, body weight, glucose homeostasis
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1111 Nutrition and Dietetics
Depositing User: VUIR
Date Deposited: 30 Aug 2013 02:46
Last Modified: 05 Apr 2019 05:08
URI: http://vuir.vu.edu.au/id/eprint/21978
DOI: https://doi.org/10.1007/s00018-013-1419-9
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Citations in Scopus: 5 - View on Scopus

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