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The cannabinoid receptor 1 and its role in influencing peripheral metabolism

O'Keefe, Lannie and Simcocks, A. C and Hryciw, Deanne H and Mathai, Michael L and McAinch, Andrew (2013) The cannabinoid receptor 1 and its role in influencing peripheral metabolism. Diabetes, Obesity and Metabolism. ISSN 1463-1326

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Abstract

Evidence from in vitro and in vivo studies has demonstrated the deleterious pathological effects of a dysregulated endocannabinoid system. Increased stimulation of the cannabinoid receptor 1 (CB1) and subsequent downstream cellular signalling are both causative in the deleterious pathological effects observed in a number of diseases. When the CB1 cell signalling cascade is blocked, this results in whole body weight-loss, leading to a reduction in obesity and associated co-morbidities. In the central nervous system; however, CB1 antagonism results in adverse psychological side effects. Blockade of CB1 via peripheral acting compounds that do not cross the blood–brain barrier have been determined to have beneficial effects in metabolic tissues such as the liver and skeletal muscle. These results support the notion that peripheral blockade of CB1 using pharmacological antagonists is a viable target for the treatment of the current epidemic of obesity and its associated co-morbidities.

Item Type: Article
Uncontrolled Keywords: cannabinoids, energy regulation, obesity therapy, weight loss therapy, appetite, energy metabolism, endocannabinoid system, ECS, mRNA expression
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1103 Clinical Sciences
FOR Classification > 1111 Nutrition and Dietetics
Depositing User: VUIR
Date Deposited: 30 Aug 2013 04:58
Last Modified: 11 Apr 2017 08:50
URI: http://vuir.vu.edu.au/id/eprint/21982
DOI: 10.1111/dom.12144
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