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S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans

Mollica, J. P and Dutka, T. L and Merry, T. L and Lamboley, C. R and McConell, Glenn K and McKenna, Michael J and Murphy, R. M and Lamb, G. D (2012) S-Glutathionylation of troponin I (fast) increases contractile apparatus Ca 2+ sensitivity in fast-twitch muscle fibres of rats and humans. Journal of Physiology, 590 (6). pp. 1443-1463. ISSN 0022-3751

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Abstract

This study demonstrates that the increase in force response appears to be due to a specific chemical process, known as S-glutathionylation, of a particular cysteine residue present on the troponin I molecule in fast-twitch muscle fibres, which is involved in sensing and responding to changes in intracellular calcium levels.

Item Type: Article
Uncontrolled Keywords: ResPubID25388, force response, cysteine residues, oxidation, skinned muscle fibres
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Funders: http://purl.org/au-research/grants/nhmrc/541938
Depositing User: Yimin Zeng
Date Deposited: 17 Dec 2013 23:11
Last Modified: 04 Mar 2015 04:40
URI: http://vuir.vu.edu.au/id/eprint/22096
DOI: 10.1113/jphysiol.2011.224535
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Citations in Scopus: 11 - View on Scopus

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