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Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering

Laker, Rhianna C and Wadley, G. D and McConell, Glenn K and Wlodek, M. E (2012) Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering. Journal of Developmental Origins of Health and Disease, 3 (1). pp. 39-51. ISSN 2040-1744

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Abstract

We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering would ameliorate these deficits. Developmental age appears to be a major factor regulating skeletal muscle mitochondrial and developmental genes, with growth restriction and cross-fostering having only subtle effects. It therefore appears that reductions in adult mitochondrial biogenesis markers likely develop after weaning.

Item Type: Article
Uncontrolled Keywords: ResPubID25781, gene expression, growth, growth restriction, skeletal muscle
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 0601 Biochemistry and Cell Biology
FOR Classification > 0604 Genetics
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Funders: http://purl.org/au-research/grants/nhmrc/454570
Depositing User: Yimin Zeng
Date Deposited: 17 Dec 2013 05:42
Last Modified: 11 Mar 2016 05:22
URI: http://vuir.vu.edu.au/id/eprint/22104
DOI: 10.1017/S204017441100064X
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Citations in Scopus: 0 - View on Scopus

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