Research Repository

The emerging role of PEDF in stem cell biology

Elahy, Mina and Baindur-Hudson, Swati and Dass, Crispin R (2012) The emerging role of PEDF in stem cell biology. Journal of Biomedicine and Biotechnology, 2012. ISSN 1110-7243 (print), 1110-7251 (online)

[img] Text
239091.pdf - Published Version
Restricted to Repository staff only

Download (1MB)

Abstract

Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.

Item Type: Article
Uncontrolled Keywords: ResPubID25815, stem cells, proteins, tissues, pigment-epithelium-derived factor
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Yimin Zeng
Date Deposited: 19 Feb 2014 03:20
Last Modified: 19 Jun 2014 05:36
URI: http://vuir.vu.edu.au/id/eprint/23162
DOI: 10.1155/2012/239091
ePrint Statistics: View download statistics for this item
Citations in Scopus: 3 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar