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The fate of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney

Verghese, Elizabeth, Johnson, Chad, Bertram, John, Ricardo, Sharon D and Deane, James (2012) The fate of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney. BMC Nephrology, 13. ISSN 1471-2369

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Abstract

Polycystic Kidney Disease (PKD) is a genetic condition in which dedifferentiated and highly proliferative epithelial cells form renal cysts and is frequently treated by renal transplantation. Studies have reported that bone marrow-derived cells give rise to renal epithelial cells, particularly following renal injury as often occurs during transplantation. This raises the possibility that bone marrow-derived cells from a PKD-afflicted recipient could populate a transplanted kidney and express a disease phenotype. However, for reasons that are not clear the reoccurrence of PKD has not been reported in a genetically normal renal graft. We used a mouse model to examine whether PKD mutant bone marrow-derived cells are capable of expressing a disease phenotype in the kidney.

Item Type: Article
Additional Information:

Article 91

Uncontrolled Keywords: ResPubID25687, mice, bone marrow-derived epithelial cells, cysts, hematopoietic stem cells, polycystic kidney disease, proliferation, renal injury, kidneys
Subjects: Current > FOR Classification > 1103 Clinical Sciences
Current > Division/Research > College of Health and Biomedicine
Depositing User: Yimin Zeng
Date Deposited: 25 Jul 2014 03:23
Last Modified: 07 Jun 2018 00:05
URI: http://vuir.vu.edu.au/id/eprint/23275
DOI: https://doi.org/10.1186/1471-2369-13-91
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Citations in Scopus: 1 - View on Scopus

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