Research Repository

Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: Impact of exercise training

Joham, Anju E, Teede, Helena J, Hutchison, Samantha K, Stepto, Nigel, Harrison, Cheryce L, Strauss, Boyd J, Paul, Eldho and Watt, Matthew J (2012) Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: Impact of exercise training. Obesity: a Research Journal, 20 (12). pp. 2390-2396. ISSN 1930-7381

Full text for this resource is not available from the Research Repository.

Abstract

Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity, and cardiovascular risk factors in obese women with polycystic ovary syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF. This prospective cohort intervention study was based at a tertiary medical center. Twenty obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition, and euglycemic–hyperinsulinemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise. Mean glucose infusion rate (GIR) was 31.7% lower (P = 0.02) in PCOS compared to controls (175.6 ± 96.3 and 257.2 ± 64.3 mg.m−2.min−1) at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR (r = −0.41, P = 0.03) and high-density lipoprotein (HDL) (r = −0.46, P = 0.01), and positively to cardiovascular risk factors, systolic (r = 0.41, P = 0.02) and diastolic blood pressure (r = 0.47, P = 0.01) and triglycerides (r = 0.49, P = 0.004). The correlation with GIR was not significant after adjusting for fat mass (P = 0.07). Exercise training maintained BMI and increased GIR in both groups; however, plasma PEDF was unchanged. In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass, and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.

Item Type: Article
Uncontrolled Keywords: ResPubID25602, polycystic ovary syndrome, PCOS, reproductive age, polycystic ovaries, ultrasound, insulin resistance, IR
Subjects: FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Funders: http://purl.org/au-research/grants/nhmrc/606553
Depositing User: Yimin Zeng
Date Deposited: 04 Feb 2014 00:43
Last Modified: 17 Feb 2015 00:35
URI: http://vuir.vu.edu.au/id/eprint/23355
DOI: https://doi.org/10.1038/oby.2012.135
ePrint Statistics: View download statistics for this item
Citations in Scopus: 14 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar