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Intramyocellular lipid variations in active older men: relationship with aerobic fitness

Rouffet, David and Villars, C and Fissoune, R and Sappey-Marinier, D and Laville, M and Ibarrola, D and Sothier, M and Monnet, M. F and Ovize, M and Bonnefoy, M and Boesch, C and Canet-Soulas, E (2012) Intramyocellular lipid variations in active older men: relationship with aerobic fitness. Acta Physiologica, 207 (3). pp. 516-523. ISSN 1748-1708 (print) 1748-1716 (online)

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Abstract

Aims Intramyocellular lipid (IMCL) variations in older men are poorly explored. In young adults, IMCL can be influenced by both diet and exercise interventions; this flexibility is related to aerobic fitness. We evaluated in active older adults the influence of maximal aerobic capacity on short-term diet and exercise-induced variations in IMCL stores. Methods Intramyocellular lipids were measured by 1H magnetic resonance spectroscopy (1H-MRS) after a 3-day fat depletion-replenishment diet (IMCLFDR) and immediately after a 2-h exercise at 50% VO2 max (IMCLFDR_EX). To further explore diet influence, the protocol was repeated after a high-fat diet (HF), with both pre- and post-exercise measurements (IMCLHF and IMCLHF_EX). Results In active older men (69.8 ± 5.2 years), IMCLFDR was lowered by exercise (IMCLFDR = 3.45 ± 1.52 vs. IMCLFDR_EX = 2.74 ± 1.15 mmol kg−1 wet weight, P < 0.05), and exercise-induced variations were correlated to the initial store (P < 0.05, r = −0.72). IMCLFDR was linked with aerobic fitness (P < 0.05, r = 0.76), when adjusted by fat mass. IMCLHF was lower than IMCLFDR (P < 0.05), decreased after exercise (P < 0.05) and varied also as a function of initial store (P < 0.05, r = −0.89), but without link with aerobic fitness. Finally, diet-induced IMCL store variations were positively linked to aerobic fitness (P < 0.05, r = 0.89). Conclusion Variations of the IMCL stores in physically active older adults appear related to aerobic fitness, with similarly fast adaptation to short-term interventions combining diet and exercise as young active adults.

Item Type: Article
Uncontrolled Keywords: ResPubID25579, exercise, lipids, magnetic resonance
Subjects: FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Yimin Zeng
Date Deposited: 21 Jul 2014 03:59
Last Modified: 07 Aug 2017 01:27
URI: http://vuir.vu.edu.au/id/eprint/23375
DOI: 10.1111/apha.12045
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