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Sgk-1 is a positive regulator of constitutive albumin uptake in renal proximal tubule cells

Hryciw, Deanne H, Kruger, Wade A, Briffa, Jessica F, Slattery, Craig, Bolithon, Adelyn, Lee, Aven and Poronnik, Philip (2012) Sgk-1 is a positive regulator of constitutive albumin uptake in renal proximal tubule cells. Cellular Physiology and Biochemistry, 30 (5). pp. 1215-1226. ISSN 1015-8987 (print) 1421-9778 (online)

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Abstract

eceptor-mediated endocytosis of albumin by the renal proximal tubule requires a number of proteins including megalin/cubilin, sodium/hydrogen exchanger isoform 3 (NHE3) and ClC-5, as well as the PSD-95/Dlg/Zo-1 (PDZ) scaffold sodium/hydrogen exchanger regulatory factor 2 (NHERF2). Despite members from the AGC kinase family, v-Akt Murine Thymoma Viral Oncogene (Akt or Protein Kinase B) and Serum/Glucocorticoid regulated Kinase 1 (Sgk-1) regulating a number of essential proteins in the albumin handling pathway, their role in uptake is largely unknown.

Item Type: Article
Uncontrolled Keywords: ResPubID25530, proximal tubule, albumin, endocytosis, Sgk-1, NHE3, NHERF2
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Yimin Zeng
Date Deposited: 23 Jul 2014 06:56
Last Modified: 23 Sep 2014 05:06
URI: http://vuir.vu.edu.au/id/eprint/23419
DOI: https://doi.org/10.1159/000343313
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Citations in Scopus: 7 - View on Scopus

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