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Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol

Weisinger, R. S and Begg, Denovan P and Denton, Derek A and Findlay, A. L. R and Kennedy, Gerard and Purcell, B and Walker, L. L and Blair-West, J. R (2009) Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol. Physiology and Behavior, 96 (4-5). pp. 637-645. ISSN 0031-9384

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Endocrine responses to fluid deprivation/restoration and preference for ethanol solution vs. water were assessed in sheep maintained for 5 months on a 10% ethanol solution as their sole source of fluid. Blood pressure, body weight, plasma composition and hormone levels of the alcohol maintained sheep were all within a normal range, except for high plasma concentrations of ANG II and ALDO. During fluid deprivation, AVP concentration increased and fluid-deprived sheep displayed a natriuresis and then a rehydration anti-natriuresis. Sheep did not drink the 10% ethanol solution avidly upon fluid restoration, preferring to drink steadily over the following 24 h; there was an associated increase in blood alcohol concentration (BAC). PRC, ANG II and ALDO all increased throughout the fluid restoration period, whereas plasma AVP and ANP gradually fell. In a separate experiment when water was also supplied to the sheep, they preferred water to 10% ethanol; however, alcohol intake was not eliminated. Overall, this degree of chronic consumption of 10% ethanol solution did not appear to adversely affect physiological mechanisms concerned with body fluid homeostasis after fluid deprivation conditions.

Item Type: Article
Uncontrolled Keywords: ResPubID19168; fluid deprivation, alcohol ingestion, drinking behavior, dehydration, renin angiotensin system, aldosterone, vasopressin, atrial natriuretic peptide
Subjects: SEO Classification > 9202 Health and Support Services
Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Depositing User: VUIR
Date Deposited: 29 Sep 2010 04:28
Last Modified: 27 Jan 2015 23:09
DOI: 10.1016/j.physbeh.2008.12.021
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Citations in Scopus: 1 - View on Scopus

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