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Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol

Weisinger, R. S, Begg, Denovan P, Denton, Derek A, Findlay, A. L. R, Kennedy, Gerard, Purcell, B, Walker, L. L and Blair-West, J. R (2009) Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol. Physiology and Behavior, 96 (4-5). pp. 637-645. ISSN 0031-9384

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Abstract

Endocrine responses to fluid deprivation/restoration and preference for ethanol solution vs. water were assessed in sheep maintained for 5 months on a 10% ethanol solution as their sole source of fluid. Blood pressure, body weight, plasma composition and hormone levels of the alcohol maintained sheep were all within a normal range, except for high plasma concentrations of ANG II and ALDO. During fluid deprivation, AVP concentration increased and fluid-deprived sheep displayed a natriuresis and then a rehydration anti-natriuresis. Sheep did not drink the 10% ethanol solution avidly upon fluid restoration, preferring to drink steadily over the following 24 h; there was an associated increase in blood alcohol concentration (BAC). PRC, ANG II and ALDO all increased throughout the fluid restoration period, whereas plasma AVP and ANP gradually fell. In a separate experiment when water was also supplied to the sheep, they preferred water to 10% ethanol; however, alcohol intake was not eliminated. Overall, this degree of chronic consumption of 10% ethanol solution did not appear to adversely affect physiological mechanisms concerned with body fluid homeostasis after fluid deprivation conditions.

Item Type: Article
Uncontrolled Keywords: ResPubID19168; fluid deprivation, alcohol ingestion, drinking behavior, dehydration, renin angiotensin system, aldosterone, vasopressin, atrial natriuretic peptide
Subjects: SEO Classification > 9202 Health and Support Services
Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Depositing User: VUIR
Date Deposited: 29 Sep 2010 04:28
Last Modified: 27 Jan 2015 23:09
URI: http://vuir.vu.edu.au/id/eprint/2345
DOI: https://doi.org/10.1016/j.physbeh.2008.12.021
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Citations in Scopus: 1 - View on Scopus

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