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Uteroplacental insufficiency programs regional vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy

Mazzuca, Marc Q, Tare, Marianne, Parkington, Helena, Dragomir, Nicoleta, Parry, Laura J and Wlodek, Mary E (2012) Uteroplacental insufficiency programs regional vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy. The Journal of Physiology, 590 (14). pp. 3375-3388. ISSN 0022-3751 (print) 1469-7793 (online)

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Intrauterine growth restriction is a risk factor for cardiovascular disease in adulthood. We have previously shown that intrauterine growth restriction caused by uteroplacental insufficiency programmes uterine vascular dysfunction and increased arterial stiffness in adult female rat offspring. The aim of this study was to investigate vascular adaptations in growth restricted female offspring when they in turn become pregnant. Uteroplacental insufficiency was induced inWKY rats by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) on day 18 of pregnancy. F0 pregnant females delivered naturally at term. F1 Control and Restricted offspring were mated at 4months of age and studied on day 20 of pregnancy. Age-matched non-pregnant F1 Control and Restricted females were also studied. Wire and pressure myography were used to test endothelial and smooth muscle function, and passive mechanical wall properties, respectively, in uterine, mesenteric, renal and femoral arteries of all four groups. Collagen and elastin fibres were quantified using polarized light microscopy and qRT-PCR. F1 Restricted females were born 10–15% lighter than Controls (P <0.05). Non-pregnant Restricted females had increased uterine and renal artery stiffness compared with Controls (P <0.05), but this difference was abolished at day 20 of pregnancy. Vascular smooth muscle and endothelial function were preserved in all arteries of non-pregnant and pregnant Restricted rats. Collagen and elastin content were unaltered in uterine arteries of Restricted females. Growth restricted females develop compensatory vascular changes during late pregnancy, such that region-specific vascular deficits observed in the non-pregnant state did not persist in late pregnancy.

Item Type: Article
Uncontrolled Keywords: ResPubID26524, uterus, placenta, programs, veins, arteries, uterine vascular dysfunction, intrauterine growth restriction, perinatal morbidity, perinatal mortality
Subjects: Current > FOR Classification > 1114 Paediatrics and Reproductive Medicine
Current > Division/Research > College of Health and Biomedicine
Depositing User: Ms Phung.T Tran
Date Deposited: 26 Mar 2014 03:10
Last Modified: 28 Feb 2020 05:36
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Citations in Scopus: 20 - View on Scopus

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