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The effect of cancer procoagulant on expression of metastatic and angiogenic markers in breast cancer and embryonic stem cell lines

Kee, Nalise Low Ah, Naude, Ryno J, Blatch, Gregory L and Frost, Carminita L (2012) The effect of cancer procoagulant on expression of metastatic and angiogenic markers in breast cancer and embryonic stem cell lines. Biological Chemistry, 393 (3). pp. 113-121. ISSN 1431-6730 (print) 1437-4315 (online)

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Abstract

Cancer procoagulant is present only in malignant tumours and the undifferentiated tissues of human placenta. Its possible role in angiogenesis and metastasis was investigated. Cancer procoagulant increased the steady-state mRNA level of L1 cell adhesion molecule (L1CAM) in MCF-7 breast cancer cells and E14 mouse embryonic stem cells (MESCs), while an increase in angiogenin mRNA was observed in MDA-MB-231 breast cancer cells. Furthermore, production of vascular endothelial growth factor (VEGF) protein in MCF-7 breast cancer cells and E14 MESCs, but decreased in MDA-MB-231 breast cancer cells. We conclude that cancer procoagulant could potentially play a part in angiogenesis in cancer and vascular development during embryonic development.

Item Type: Article
Uncontrolled Keywords: ResPubID26527, angiogenesis, cancer procoagulant, metastasis, VEGF
Subjects: Current > FOR Classification > 0601 Biochemistry and Cell Biology
Current > Division/Research > College of Health and Biomedicine
Depositing User: Ms Phung.T Tran
Date Deposited: 26 Feb 2014 06:03
Last Modified: 02 Mar 2020 00:08
URI: http://vuir.vu.edu.au/id/eprint/23645
DOI: https://doi.org/10.1515/hsz-2011-0177
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Citations in Scopus: 4 - View on Scopus

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