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Co-nanoencapsulated doxorubicin and Dz13 control osteosarcoma progression in a murine model

Tan, Mei Lin and Friedhuber, Anna M and Dass, Crispin R (2013) Co-nanoencapsulated doxorubicin and Dz13 control osteosarcoma progression in a murine model. Journal of Pharmacy and Pharmacology, 65 (1). pp. 35-43. ISSN 0022-3573 (print) 2042-7158 (online)

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Abstract

Chitosan is a green (natural, abundant, biodegradable, biocompatible) biopolymer that can be formulated to encapsulate a variety of therapeutic compounds. This study aimed to investigate chitosan nanoparticles (NPs) as a means of improving delivery of the clinically used anti-cancer agent doxorubicin (Dox) and the preclinical lead compound Dz13 oligonucleotide together.

Item Type: Article
Uncontrolled Keywords: ResPubID26666, ResPubID25471, chemotherapy, chitosan, DNA, drug delivery, nanoparticles, cancer
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Depositing User: Ms Phung.T Tran
Date Deposited: 18 Jul 2014 06:31
Last Modified: 04 Aug 2014 05:30
URI: http://vuir.vu.edu.au/id/eprint/23713
DOI: 10.1111/j.2042-7158.2012.01572.x
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