Research Repository

The FTO A/T polymorphism and elite athletic performance: A study involving three groups of European athletes

Eynon, Nir and Nasibulina, Emiliya S and Banting, Lauren K and Cieszczyk, Pawel and Maciejewska-Karlowska, Agnieszka and Sawczuk, Marek and Bondareva, Elvira A and Shagimardanova, Roza R and Raz, Maytal and Sharon, Yael and Williams, Alun G and Ahmetov, Ildus I and Lucia, Alejandro and Birk, Ruth (2013) The FTO A/T polymorphism and elite athletic performance: A study involving three groups of European athletes. PLoS ONE, 8 (4). ISSN 1932-6203

[img]
Preview
Text
journal.pone.0060570.pdf - Published Version

Download (246kB) | Preview

Abstract

Objective: The FTO A/T polymorphism (rs9939609) is a strong candidate to influence obesity-related traits. Elite athletes from many different sporting disciplines are characterized by low body fat. Therefore, the aim of this study was to assess whether athletic status is associated with the FTO A/T polymorphism. Subjects and Methods: A large cohort of European Caucasians from Poland, Russia and Spain were tested to examine the association between FTO A/T polymorphism (rs9939609) and athletic status. A total of 551 athletes were divided by type of sport (endurance athletes, n = 266 vs. sprint/power athletes, n = 285) as well as by level of competition (elite-level vs. national-level). The control group consisted of 1,416 ethnically-matched, non-athletic participants, all Europeans. Multinomial logistic regression analyses were conducted to assess the association between FTO A/T genotypes and athletic status/competition level. Results: There were no significantly greater/lesser odds of harbouring any type of genotype when comparing across athletic status (endurance athletes, sprint/power athletes or control participants). These effects were observed after controlling for sex and nationality. Furthermore, no significantly greater/lesser odds ratios were observed for any of the genotypes in respect to the level of competition (elite-level vs. national-level). Conclusion: The FTO A/T polymorphism is not associated with elite athletic status in the largest group of elite athletes studied to date. Large collaborations and data sharing between researchers, as presented here, are strongly recommended to enhance the research in the field of exercise genomics. E-pub: e60570

Item Type: Article
Uncontrolled Keywords: adolescent, adult, athletes, athletic performance, case-control studies, European Continental Ancestry Group, female, Genetic Association Studies
Subjects: FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > School of Sport and Exercise Science
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 15 Jan 2014 23:34
Last Modified: 29 Jul 2016 01:52
URI: http://vuir.vu.edu.au/id/eprint/23866
DOI: 10.1371/journal.pone.0060570
ePrint Statistics: View download statistics for this item
Citations in Scopus: 5 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar