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Features of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: a prospective study in Mauritius

Boyko, E. J, de Courten, Maximilian, Zimmet, P. Z, Chitson, P, Tuomilehto, J and Alberti, K. G. M. M (2000) Features of the metabolic syndrome predict higher risk of diabetes and impaired glucose tolerance: a prospective study in Mauritius. Diabetes Care, 23 (9). pp. 1242-1248. ISSN 0149-5992 (print) 1935-5548 (online)

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Abstract

OBJECTIVE: To assess the independent and joint effects of the components of the metabolic syndrome, including leptin, which is a recently proposed addition to this syndrome, in predicting the cumulative incidence of impaired glucose tolerance (IGT) and diabetes among individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS: This prospective study involved 2,605 residents of Mauritius with normal glucose tolerance who were followed for 5 years for IGT or diabetes onset in relation to total and regional adiposity (BMI, waist-to-hip ratio [WHR]), fasting and 2-h 75-g oral glucose load glucose and insulin, total and HDL cholesterol, blood pressure, serum uric acid, triglyceride, and leptin levels. RESULTS: A multivariate logistic regression model adjusted for age, sex, ethnicity, and diabetes family history showed a significantly higher linear increase in risk of IGT and diabetes in association with the following variables only: fasting glucose (odds ratio 1.89 [95% CI 1.51-2.34]), 2-h glucose (1.68 [1.50-1.88]), WHR (1.30 [1.10-1.52]), BMI (1.04 [1.00-1.08]), and serum uric acid (1.37 [1.20-1.57]). However, a nonlinear increase was seen with serum triglyceride and plasma leptin concentrations. No risk factors resulted in joint effects that were greater than expected from combining individual effects. CONCLUSIONS: Metabolic syndrome features independently predict a higher risk of diabetes or IGT in normoglycemic subjects but in combination confer no higher-than-expected risk of these outcomes. At higher concentrations of triglycerides and leptin, risk plateaus and even declines slightly.

Item Type: Article
Uncontrolled Keywords: obesity, impaired glucose tolerance, oral glucose, insulin, high risk population, glucose blood level, cholesterol blood level, serum uric acid, triglyceride, leptin, serum triglyceride, plasma leptin concentrations, clinical study
Subjects: FOR Classification > 1103 Clinical Sciences
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Ms Julie Gardner
Date Deposited: 15 Jul 2014 01:07
Last Modified: 15 Jul 2014 01:07
URI: http://vuir.vu.edu.au/id/eprint/25433
DOI: https://doi.org/10.2337/diacare.23.9.1242
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Citations in Scopus: 81 - View on Scopus

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