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Rapid actions of insulin on sensory nerve function

Delaney, Carol A, Murchie, Karen J, Westerman, Roderick A and de Courten, Maximilian (1998) Rapid actions of insulin on sensory nerve function. NeuroReport, 9 (12). pp. 2775-2779. ISSN 0959-4965 (print) 1473-558X (online)

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THE acute action of insulin on neurogenic flare was investigated using iontophoresis. Twenty-five patients with insulin-dependent diabetes mellitus (IDDM) and 25 age- and gender-matched controls were studied. Axon reflex vasodilatation was evoked by transdermal iontophoresis of acetylcholine (ACh) before and after skin treatment by the iontophoresis of insulin and measured using laser Doppler velocimetry. Axon reflex responses were reduced in IDDM patients compared with controls (p < 0.001) but were restored after the iontophoresis of insulin. Insulin iontophoresis had no effect on the size of the axon reflex response in control subjects (p < 0.05). This study confirms the reduction of the ACh-induced flare in human patients with IDDM and has demonstrated relatively rapid effects of insulin on this cutaneous neurogenic response.

Item Type: Article
Uncontrolled Keywords: axon reflex, hyperglycemia, insulin deficiency, insulin-dependent diabetes mellitus, Iontophoresis, laser Doppler flowmetry, neurogenic flare, primary afferents, thermal thresholds, vasodilation
Subjects: FOR Classification > 1109 Neurosciences
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Ms Julie Gardner
Date Deposited: 16 Jul 2014 04:58
Last Modified: 06 Feb 2015 00:29
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Citations in Scopus: 9 - View on Scopus

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