Research Repository

Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study

Zimmet, Paul, Hodge, Allison, Nicolson, Margery, Staten, Myrlene, de Courten, Maximilian, Moore, Jason, Morawiecki, Andrew, Lubina, John, Collier, Greg R, Alberti, George and Dowse, Gary (1996) Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. BMJ, 313 (7063). pp. 965-969. ISSN 0959-8138 (print) 1756-1833 (online)

Full text for this resource is not available from the Research Repository.

Abstract

Objective: To measure serum leptin concentrations in the Polynesian population of Western Samoa and to examine epidemiological associations of leptin with anthropometric, demographic, behavioural, and metabolic factors in this population with a high prevalence of obesity and non-insulin dependent diabetes mellitus. Design: Cross sectional study, leptin concentration being measured in a subgroup of a population based sample. Subjects: 240 Polynesian men and women aged 28–74 years were selected to cover the full range of age, body mass index, and glucose tolerance. Main outcome measurements: Serum leptin, insulin, and glucose concentrations; anthropometric measures; physical activity; and area of residence. Results: Leptin concentrations were correlated with body mass index (r = 0.80 in men, 0.79 in women) and waist circumference (r = 0.82 in men, 0.78 in women) but less so with waist to hip ratio. At any body mass index, leptin concentration was higher in women than men (geometric mean adjusted for body mass index 15.3 v 3.6 pg/1, P<0.001). Leptin concentration also correlated with fasting insulin concentration (r = 0.63 in men, 0.64 in women) and insulin concentration 2 hours after a glucose load (r = 0.58 in men, 0.52 in women). These associations remained significant after controlling for body mass index; effects of physical activity and of rural or urban living on leptin concentration were eliminated after adjusting for obesity, except values remained high in urban men. 78% of variance in leptin was explained by a model including fasting insulin concentration, sex, body mass index, and a body mass index by sex interaction term. Similar results were obtained if waist circumference replaced body mass index. Conclusions: The strong relation of leptin with obesity is consistent with leptin production being proportional to mass of adipose tissue. The relation with insulin independent of body mass index suggests a possible role for leptin in insulin resistance or hyperinsulinaemia.

Item Type: Article
Uncontrolled Keywords: insulin, glucose concentrations, anthropometric measures, physical activity, hyperinsulinaemia
Subjects: FOR Classification > 1103 Clinical Sciences
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Ms Julie Gardner
Date Deposited: 17 Jul 2014 00:45
Last Modified: 30 Jan 2015 03:05
URI: http://vuir.vu.edu.au/id/eprint/25516
DOI: https://doi.org/10.1136/bmj.313.7063.965
ePrint Statistics: View download statistics for this item
Citations in Scopus: 200 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar