Research Repository

Effects of Nonlinear Aerobic Training on Erectile Dysfunction and Cardiovascular Function Following Radical Prostatectomy for Clinically Localized Prostate Cancer

Jones, Lee W, Hornsby, Whitney E, Freedland, Stephen J, Lane, Amy, West, Miranda J, Moul, Judd W, Ferrandino, Michael N, Allen, Jason, Kenjale, Aarti A, Thomas, Samantha M, Herndon II, James E, Koontz, Bridget F, Chan, June M, Khouri, Michel G, Douglas, Pamela S and Eves, Neil D (2013) Effects of Nonlinear Aerobic Training on Erectile Dysfunction and Cardiovascular Function Following Radical Prostatectomy for Clinically Localized Prostate Cancer. European Urology, 65 (5). pp. 852-855. ISSN 0302-2838 (print) 1873-7560 (online)

Full text for this resource is not available from the Research Repository.

Abstract

Erectile dysfunction (ED) is a major adverse effect of radical prostatectomy (RP). We conducted a randomized controlled trial to examine the efficacy of aerobic training (AT) compared with usual care (UC) on ED prevalence in 50 men (n = 25 per group) after RP. AT consisted of five walking sessions per week at 55–100% of peak oxygen uptake (VO2peak) for 30–60 min per session following a nonlinear prescription. The primary outcome was change in the prevalence of ED, as measured by the International Index of Erectile Function (IIEF), from baseline to 6 mo. Secondary outcomes were brachial artery flow–mediated dilation (FMD), VO2peak, cardiovascular (CV) risk profile (eg, lipid profile, body composition), and patient-reported outcomes (PROs). The prevalence of ED (IIEF score ≤21) decreased by 20% in the AT group and by 24% in the UC group (difference: p = 0.406). There were no significant between-group differences in any erectile function subscale (p > 0.05). Significant between-group differences were observed for changes in FMD and VO2peak, favoring AT. There were no group differences in other markers of CV risk profile or PROs. In summary, nonlinear AT does not improve ED in men with localized prostate cancer in the acute period following RP.

Item Type: Article
Uncontrolled Keywords: exercise training, prostate cancer, efficacy, exercise capacity, endothelial function
Subjects: FOR Classification > 1103 Clinical Sciences
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Ms Julie Gardner
Date Deposited: 23 Sep 2014 02:05
Last Modified: 23 Sep 2014 03:35
URI: http://vuir.vu.edu.au/id/eprint/25739
DOI: https://doi.org/10.1016/j.eururo.2013.11.009
ePrint Statistics: View download statistics for this item
Citations in Scopus: 23 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar