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Potential Mechanisms for Reduced Delivery of Nitric Oxide to Peripheral Tissues in Diabetes Mellitus

Stabler, Thomas, Kenjale, Aarti A, Ham, Katherine L, Jelesoff, Nicole and Allen, Jason (2010) Potential Mechanisms for Reduced Delivery of Nitric Oxide to Peripheral Tissues in Diabetes Mellitus. Annals of the New York Academy of Sciences, 1203. pp. 101-106. ISSN 0077-8923 (print) 1749-6632 (online)

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Abstract

Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise training improves endothelial function but its effect on NO bioavailability in peripheral tissues during acute exercise stress in CVD is unclear. This paper will present evidence and discuss possible mechanisms by which NO delivery to peripheral tissues may be dysfunctional in diabetic subjects.

Item Type: Article
Uncontrolled Keywords: nitric oxide, diabetes mellitus, vascular
Subjects: FOR Classification > 1103 Clinical Sciences
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Ms Julie Gardner
Date Deposited: 24 Sep 2014 07:02
Last Modified: 10 Mar 2015 04:53
URI: http://vuir.vu.edu.au/id/eprint/25756
DOI: https://doi.org/10.1111/j.1749-6632.2010.05599.x
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Citations in Scopus: 17 - View on Scopus

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