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Plasma nitrite response and arterial reactivity differentiate vascular health and performance

Allen, Jason, Miller, Elizabeth M, Schwark, Earl, Robbins, Jennifer L, Duscha, Brian D and Annex, Brian H (2009) Plasma nitrite response and arterial reactivity differentiate vascular health and performance. Nitric Oxide: Biology and Chemistry, 20 (4). pp. 231-237. ISSN 1089-8603

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Abstract

NO is crucial for endothelial function and vascular health. Plasma nitrite (NO2−) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO2− response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were: (a) risk factors but no vascular disease (RF); (b) Type 2 diabetes with no vascular disease (DM); (c) diagnosed peripheral arterial disease (PAD); and (d) DM + PAD. Venous blood was drawn at rest and 10 min following maximal exercise. Plasma samples were analyzed by reductive chemiluminescence. Brachial diameters were imaged prior to, during and following 5 min of forearm occlusion (BAFMD). There were no differences in resting plasma NO2− or BA diameters between groups. The PAD groups had lower age adjusted BAFMD responses (p ⩽ 0.05). Within group analysis revealed an increase in NO2− in the RF group (+39.3%), no change in the DM (−15.51%), and a decrease in the PAD (−44.20%) and PAD + DM (−39.95%). This was maintained after adjusting for age and VO2peak (p ⩽ 0.05). ΔNO2− and BAFMD were the strongest independent predictors of VO2peak in multivariate linear regression. These findings suggest ΔNO2− discriminates severity of cardiovascular disease risk, is related to endothelial function and predicts exercise capacity.

Item Type: Article
Uncontrolled Keywords: endothelium, nitric oxide, plasma nitrite, cardiovascular disease, exercise, VO2peak
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Ms Julie Gardner
Date Deposited: 26 Sep 2014 05:24
Last Modified: 26 Sep 2014 05:24
URI: http://vuir.vu.edu.au/id/eprint/25758
DOI: https://doi.org/10.1016/j.niox.2009.01.002
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Citations in Scopus: 47 - View on Scopus

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