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Lower-limb vascular imaging with acoustic radiation force elastography: Demonstration of in vivo feasibility

Dumont, Douglas, Dahl, Jeremy J, Miller, Elizabeth, Allen, Jason, Fahey, Brian and Trahey, Gregg (2009) Lower-limb vascular imaging with acoustic radiation force elastography: Demonstration of in vivo feasibility. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 56 (5). pp. 931-944. ISSN 0885-3010

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Acoustic radiation force impulse (ARFI) imaging characterizes the mechanical properties of tissue by measuring displacement resulting from applied ultrasonic radiation force. In this paper, we describe the current status of ARFI imaging for lower-limb vascular applications and present results from both tissue-mimicking phantoms and in vivo experiments. Initial experiments were performed on vascular phantoms constructed with polyvinyl alcohol for basic evaluation of the modality. Multilayer vessels and vessels with compliant occlusions of varying plaque load were evaluated with ARFI imaging techniques. Phantom layers and plaque are well resolved in the ARFI images, with higher contrast than B-mode, demonstrating the ability of ARFI imaging to identify regions of different mechanical properties. Healthy human subjects and those with diagnosed lower-limb peripheral arterial disease were imaged. Proximal and distal vascular walls are well visualized in ARFI images, with higher mean contrast than corresponding B-mode images. ARFI images reveal information not observed by conventional ultrasound and lend confidence to the feasibility of using ARFI imaging during lower-limb vascular workup.

Item Type: Article
Uncontrolled Keywords: biomechanics, biomedical ultrasonics, blood vessels, diseases, phantoms
Subjects: Current > FOR Classification > 0203 Classical Physics
Current > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Current > Division/Research > College of Sports and Exercise Science
Depositing User: Ms Julie Gardner
Date Deposited: 26 Sep 2014 06:17
Last Modified: 04 Feb 2015 01:25
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Citations in Scopus: 42 - View on Scopus

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