Dahl, Jeremy J, Dumont, Douglas M, Allen, Jason, Miller, Elizabeth M and Trahey, Gregg E (2009) Acoustic Radiation Force Impulse Imaging for Noninvasive Characterization of Carotid Artery Atherosclerotic Plaques: A Feasibility Study. Ultrasound in Medicine and Biology, 35 (5). pp. 707-716. ISSN 0301-5629

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Abstract

Atherosclerotic disease in the carotid artery is a risk factor for stroke. The susceptibility of atherosclerotic plaque to rupture, however, is challenging to determine by any imaging method. In this study, acoustic radiation force impulse (ARFI) imaging is applied to atherosclerotic disease in the carotid artery to determine the feasibility of using ARFI to noninvasively characterize carotid plaques. ARFI imaging is a useful method for characterizing the local mechanical properties of tissue and is complementary to B-mode imaging. ARFI imaging can readily distinguish between stiff and soft regions of tissue. High-resolution images of both homogeneous and heterogeneous plaques were observed. Homogeneous plaques were indistinguishable in stiffness from vascular tissue. However, they showed thicknesses much greater than normal vascular tissue. In heterogeneous plaques, large and small soft regions were observed, with the smallest observed soft region having a diameter of 0.5 mm. A stiff cap was observed covering the large soft tissue region, with the cap thickness ranging from 0.7–1.3 mm. (E-mail: jeremy.dahl@duke.edu)

Item Type:	Article
Uncontrolled Keywords:	ultrasound, ultrasonic imaging, atherosclerosis, carotid plaque, radiation force, ARFI
Subjects:	FOR Classification > 0903 Biomedical Engineering FOR Classification > 1102 Cardiorespiratory Medicine and Haematology Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User:	Ms Julie Gardner
Date Deposited:	26 Sep 2014 06:43
Last Modified:	26 Sep 2014 06:43
URI:	http://vuir.vu.edu.au/id/eprint/25760
DOI:	https://doi.org/10.1016/j.ultrasmedbio.2008.11.001
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Citations in Scopus:	85 - View on Scopus

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