Research Repository

Biphasic responses of the brachial artery diameter following forearm occlusion: a blunted response in the elderly

Dobrosielski, Devon A, Arce, Arturo A, Allen, Jason, Wood, Robert H and Welsch, Michael A (2006) Biphasic responses of the brachial artery diameter following forearm occlusion: a blunted response in the elderly. Dynamic Medicine, 5 (1). ISSN 1476-5918

Full text for this resource is not available from the Research Repository.

Abstract

Background The purpose was to examine the temporal response of the brachial artery diameter following 5 minutes of forearm occlusion in young men. A secondary objective was to compare the main features of the temporal pattern between young and old. Methods Sixteen young (28 ± 8 yrs) and fifteen older (85 ± 8 yrs) men underwent high-resolution ultrasonography of the brachial artery before and after five minutes of forearm occlusion. Results Following release of the pressure cuff the brachial artery diameter exhibits a temporal biphasic response. Initially, there is a significant reduction in brachial diameter (NIL) compared to baseline (BASE), followed by a rapid increase to a PEAK at 41 sec post release. When comparing the magnitude of the decrease in diameter and the Brachial Artery Flow Mediated Dilation (BAFMD) between Young and Old, older subjects demonstrated a blunted response (Magnitude of Decrease: Young: 2.0%; Old: 0.4%, p = 0.015, and BAFMD: Young: 7.7%; Old: 2.3%, p = 0.001). Finally, a significant relationship was noted between the magnitude of decrease and BAFMD (r = -0.44, p = 0.04). Conclusion Examination of the temporal response of the brachial artery diameter following 5 minutes of forearm occlusion reveals a biphasic pattern in all participants. Specific features of this pattern are blunted in older adults compared with younger subjects. Finally, the magnitude of the drop in diameter following forearm occlusion correlates with the magnitude of the BAFMD.

Item Type: Article
Uncontrolled Keywords: brachial artery, ultrasonography, flow-mediated dilation, vascular function,
Subjects: FOR Classification > 1103 Clinical Sciences
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Ms Julie Gardner
Date Deposited: 19 Nov 2014 03:21
Last Modified: 19 Nov 2014 03:21
URI: http://vuir.vu.edu.au/id/eprint/25764
DOI: https://doi.org/10.1186/1476-5918-5-4
ePrint Statistics: View download statistics for this item
Citations in Scopus: 8 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar