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An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat

Hallam, Karen and Horgan, J and McGrath, Caroline and Norman, T (2004) An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat. Behavioural Brain Research, 153 (2). pp. 481-486. ISSN 0166-4328

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Abstract

The olfactory bulbectomised (OB) rat is being increasingly used as a model of impaired learning and mnemonic functioning. In this study the model has been utilised to determine the effect of the acetylcholinesterase inhibiting compounds tacrine and physostigmine on spatial working memory deficits associated with the OB rat. One-hundred and twenty male rats were randomly allocated to OB or sham operated groups and received chronic i.p. treatment with either saline, physostigmine (0.1 mg/kg) or tacrine (0.1 and 0.3 mg/kg). Two weeks after beginning treatment animals were tested on the Morris water maze and open field test. The results indicated that the OB surgery was associated with spatial working memory disturbances that were effectively attenuated with both doses of tacrine, but not physostigmine. Increased hyperactivity and defacation was observed in OB animals in the Open-field test, however, these changes were not ameliorated by either drug treatment. The ability for tacrine but not physostigmine to attenuate OB cognitive deficits may be associated with the different half-life of these compounds. This study provides further support for the use of the OB rat as a drug discovery model for the investigation of novel therapeutic compounds that target the cholinergic system.

Item Type: Article
Uncontrolled Keywords: ResPubID16576, Olfactory bulbectomy, Spatial working memory, Acetylcholine, Tacrine, Physostigmine, Morris water maze, Open-field test, Alzheimers disease
Subjects: Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
FOR Classification > 1109 Neurosciences
Depositing User: VUIR
Date Deposited: 31 Aug 2011 07:10
Last Modified: 01 May 2012 03:02
URI: http://vuir.vu.edu.au/id/eprint/2588
DOI: 10.1016/j.bbr.2004.01.005
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Citations in Scopus: 10 - View on Scopus

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