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Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity
Kong, Lih L and Omar, A. R and Hair-Bejo, M and Aini, I and Seow, Heng-Fong (2004) Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity. Archives of Virology, 149 (2). pp. 425-434. ISSN 0304-8608
Full text for this resource is not available from the Research Repository.Abstract
The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.
Item Type: | Article |
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Uncontrolled Keywords: | ResPubID19029, Infectious bursal disease virus, IBDV, ancestral virus |
Subjects: | Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences FOR Classification > 1107 Immunology |
Depositing User: | VUIR |
Date Deposited: | 01 Feb 2012 22:22 |
Last Modified: | 12 Mar 2015 06:40 |
URI: | http://vuir.vu.edu.au/id/eprint/2616 |
DOI: | 10.1007/s00705-003-0206-6 |
ePrint Statistics: | View download statistics for this item |
Citations in Scopus: | 19 - View on Scopus |
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