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Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity

Kong, Lih L and Omar, A. R and Hair-Bejo, M and Aini, I and Seow, Heng-Fong (2004) Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity. Archives of Virology, 149 (2). pp. 425-434. ISSN 0304-8608

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Abstract

The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.

Item Type: Article
Uncontrolled Keywords: ResPubID19029, Infectious bursal disease virus, IBDV, ancestral virus
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1107 Immunology
Depositing User: VUIR
Date Deposited: 01 Feb 2012 22:22
Last Modified: 12 Mar 2015 06:40
URI: http://vuir.vu.edu.au/id/eprint/2616
DOI: 10.1007/s00705-003-0206-6
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Citations in Scopus: 19 - View on Scopus

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