Kong, Lih L, Omar, A. R, Hair-Bejo, M, Aini, I and Seow, Heng-Fong (2004) Sequence analysis of both genome segments of two very virulent Infectious bursal disease virus field isolates with distinct pathogenicity. Archives of Virology, 149 (2). pp. 425-434. ISSN 0304-8608

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Abstract

The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.

Item Type:	Article
Uncontrolled Keywords:	ResPubID19029, Infectious bursal disease virus, IBDV, ancestral virus
Subjects:	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Current > FOR Classification > 1107 Immunology
Depositing User:	VUIR
Date Deposited:	01 Feb 2012 22:22
Last Modified:	12 Mar 2015 06:40
URI:	http://vuir.vu.edu.au/id/eprint/2616
DOI:	https://doi.org/10.1007/s00705-003-0206-6
ePrint Statistics:	View download statistics for this item
Citations in Scopus:	24 - View on Scopus

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