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Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists

Begg, Denovan P, Hallam, Karen and Norman, Trevor R (2005) Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. Behavioural Brain Research, 161 (2). pp. 286-290. ISSN 0166-4328

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Administration of benzodiazepines is known to be associated with tolerance and a withdrawal syndrome on abrupt cessation. The aetiology of the withdrawal syndrome is not known but a role for the serotonin (5HT) system is suspected. The aim of the current study was to investigate the usefulness of 5-HT2 antagonists in the treatment of benzodiazepine withdrawal syndrome in the rat. Male Wistar rats were treated with either diazepam (4 mg/kg) or vehicle for 14 days, then abruptly withdrawn for 24 h. Animals were tested in the social interaction paradigm and elevated plus maze. Some diazepam-withdrawn rats were pre-treated with 5HT2 antagonists 60 min before behavioural testing. Acute withdrawal from benzodiazepines significantly reduced social interaction between pairs compared to vehicle or diazepam-treated animals. Similarly, for the elevated plus maze withdrawn animals made fewer entries and spent less time on the open arms than did vehicle or diazepam-treated animals. Single doses of 5-HT2 antagonists, mianserin (5 mg/kg) and ritanserin (1 mg/kg), effectively ameliorated withdrawal anxiety in the rat, returning behavioural function in the social interaction test and elevated plus maze to levels comparable to vehicle-treated animals.

Item Type: Article
Uncontrolled Keywords: ResPubID16574, Benzodiazepine withdrawal, 5-HT2 antagonists, anxiety, elevated plus maze, social interaction test, Diazepam
Subjects: Historical > Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Current > FOR Classification > 1109 Neurosciences
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Depositing User: VUIR
Date Deposited: 28 Mar 2012 02:52
Last Modified: 16 Feb 2015 23:06
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Citations in Scopus: 12 - View on Scopus

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