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Selective gene delivery for cancer therapy using cationic liposomes: In vivo proof of applicability

Dass, Crispin R and Choong, Peter F. M (2006) Selective gene delivery for cancer therapy using cationic liposomes: In vivo proof of applicability. Journal of Controlled Release, 113 (2). pp. 155-163. ISSN 0168-3659

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Targeted gene therapy is essential if cancer treatment is to become a reality with this form of therapy. In the past few years, cationic liposomes, discovered 2 decades ago, and at present, the most commonly used class of transfection reagents, have been tested in various clinical trials for diseases not restricted to cancer. They have been shown to be selective for tumour vascular endothelial cells raising hopes for antiangiogenic and antivascular therapies. They are also capable of being selectively delivered to the lungs and liver when administered intravenously. These vesicles are also being targeted to the tumour in various parts of the body by using advanced liposomal systems such as antibody–antigen and ligand–receptor combinations. This review looks at the state of play in this rapidly growing field.

Item Type: Article
Uncontrolled Keywords: ResPubID18889, cancer, gene therapy, cationic liposome, lipoplex, targeted, DNA
Subjects: Current > FOR Classification > 1103 Clinical Sciences
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Depositing User: VUIR
Date Deposited: 20 Apr 2012 06:52
Last Modified: 19 Jun 2014 06:25
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Citations in Scopus: 85 - View on Scopus

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