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A complementary role for the tetraspanins CD37 and Tssc6 in the immune system

Gartlan, Kate Helen (2008) A complementary role for the tetraspanins CD37 and Tssc6 in the immune system. PhD thesis, Victoria University.

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Abstract

The co-operative nature of tetraspanin-tetraspanin interactions in membrane organisation suggests that functional overlap is likely to be a factor in tetraspanin biology. CD37 and Tssc6 are immune/haematopoietic restricted tetraspanins, whose function has been previously investigated with CD37"7" and TSSC6"7" knockout mice. Both strains display hyper-proliferative T cell responses to in vitro stimulation, suggesting that functional overlap may occur between these two tetraspanin molecules in the immune system. To test this hypothesis, the immunophenotype of a tetraspanin "double knockout' mouse (CDST^Tssce-7") is described.

Item Type: Thesis (PhD thesis)
Uncontrolled Keywords: membrane proteins, T cells, B cells, NKT cells, molecules, lymphocytes, in vivo DC migration, in vitro cellular immunity
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
Faculty/School/Research Centre/Department > School of Engineering and Science
Depositing User: VU Library
Date Deposited: 08 Sep 2015 00:02
Last Modified: 08 Sep 2015 00:02
URI: http://vuir.vu.edu.au/id/eprint/29497
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