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Pigment epithelium-derived factor: a multimodal tumor inhibitor

Ek, Eugene T. H, Dass, Crispin R and Choong, Peter F. M (2006) Pigment epithelium-derived factor: a multimodal tumor inhibitor. Molecular Cancer Therapeutics , 5 (7). pp. 1641-1646. ISSN 1535-7163

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Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has been known for years to be aberrantly expressed in ocular disorders, but in recent years, down-regulation has been shown to be prevalent in a range of cancers as well. This review describes the trimodal anticancer activities of this interesting protein: antiangiogenesis, apoptosis-mediated tumor suppression, and tumor cell differentiation. The key to successful antitumor therapy with this protein is the ability to synthesize the recombinant form of the protein (or its active shortened forms) and deliver at therapeutic doses or alternatively to use gene transfer technology to prolong the effect in vivo. Although there is a substantial amount of work carried out at the preclinical stage with this protein, more groundwork has to be done before PEDF is tested against cancer in clinical trials

Item Type: Article
Uncontrolled Keywords: ResPubID18888, PEDF, tumor angiogenesis, cancer therapy
Subjects: Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 1112 Oncology and Carcinogenesis
Depositing User: VUIR
Date Deposited: 23 Apr 2012 03:09
Last Modified: 03 Feb 2015 05:52
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Citations in Scopus: 70 - View on Scopus

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