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Developmental Programming of Fetal Skeletal Muscle and Adipose Tissue Development

Yan, Xu ORCID: 0000-0001-8547-4210, Zhu, MJ, Dodson, MV and Du, M (2013) Developmental Programming of Fetal Skeletal Muscle and Adipose Tissue Development. Journal of Genomics, 1. 29 - 38.

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Abstract

All important developmental milestones are accomplished during the fetal stage, and nutrient fluctuation during this stage produces lasting effects on offspring health, so called fetal programming or developmental programming. The fetal stage is critical for skeletal muscle development, as well as adipose and connective tissue development. Maternal under-nutrition at this stage affects the proliferation of myogenic precursor cells and reduces the number of muscle fibers formed. Maternal over-nutrition results in impaired myogenesis and elevated adipogenesis. Because myocytes, adipocytes and fibrocytes are all derived from mesenchymal stem cells, molecular events which regulate the commitment of stem cells to different lineages directly impact fetal muscle and adipose tissue development. Recent studies indicate that microRNA is intensively involved in myogenic and adipogenic differentiation from mesenchymal stem cells, and epigenetic changes such as DNA methylation are expected to alter cell lineage commitment during fetal muscle and adipose tissue development.

Item Type: Article
Uncontrolled Keywords: fetal programming; maternal obesity; maternal nutrient; fetal muscle
Subjects: FOR Classification > 1111 Nutrition and Dietetics
FOR Classification > 1116 Medical Physiology
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
Depositing User: Symplectic Elements
Date Deposited: 01 Jun 2016 23:36
Last Modified: 03 Aug 2016 15:53
URI: http://vuir.vu.edu.au/id/eprint/30769
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