Effects of high-intensity training on components of muscle pH regulation
McGinley, Cian (2015) Effects of high-intensity training on components of muscle pH regulation. PhD thesis, Victoria University.
MCGINLEY Cian - Thesis.pdf
Regulation of pH in skeletal muscle comprises intracellular buffering of hydrogen ions (H+) and acid/base (H+/HCO3−) transport across the sarcolemma. During high-intensity exercise H+ transport is primarily lactate-coupled through the monocarboxylate transporters (MCT)1/4, with non-lactate-coupled transport provided by the sodium/hydrogen exchanger (NHE) system. The chaperone protein basigin is essential for MCT functioning. Intracellular buffering comprises metabolic and physicochemical buffering (βm), the latter mainly from the histidine-based proteins and dipeptides, and inorganic phosphate. The sodium-coupled bicarbonate transport proteins (NCBT) enhance intracellular buffering and H+ efflux, while the cytosolic and sarcolemmal carbonic anhydrase (CA) isozymes may enhance activity of each transport system by physical or functional interactions.
|Item Type:||Thesis (PhD thesis)|
|Uncontrolled Keywords:||intense exercise, muscles, isoforms, acid, biopsies, acid/base transport, transporters, acid-base, transmembrane, sprints, repeated sprint ability|
|Subjects:||FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > College of Sports and Exercise Science
|Depositing User:||VU Library|
|Date Deposited:||05 Jul 2016 06:16|
|Last Modified:||05 Jul 2016 06:16|
|ePrint Statistics:||View download statistics for this item|
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