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Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood

Sakuyama, H, Katoh, M, Wakabayashi, H, Zulli, Anthony, Kruzliak, P and Uehara, Y (2016) Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood. Journal of Biomedical Science, 23 (1). ISSN 1021-7770

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Abstract

Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in growth of a fetus and the development of growth-related disease in adulthood. Salt restriction causes retardation of fatal growth or intrauterine death thereby leading to low birth weight or decreased birth rate. Such retardation of growth along with the upregulation of the renin angiotensin system due to salt restriction results in the underdevelopment of cardiovascular organs or decreases the number of the nephron in the kidney and is responsible for onset of hypertension in adulthood. In addition, gestational salt restriction is associated with salt craving after weaning. Moreover, salt restriction is associated with a decrease in insulin sensitivity. A series of alterations in metabolism due to salt restriction are probably mediated by the upregulation of the renin angiotensin system and an epigenetic mechanism including proinflammatory substances or histone methylation. Part of the metabolic disease in adulthood may be programmed through such epigenetic changes. The modification of gene in a fetus may be switched on through environment factors or life style after birth. The benefits of salt restriction have been assumed thus far; however, more precise investigation is required of its influence on the health of fetuses and the onset of various diseases in adulthood.

Item Type: Article
Uncontrolled Keywords: Salt restriction; Low birth weight; Low birth rate; Programing; Growth retardation; Hypertension; Salt sensitivity; Insulin resistance; Dyslipidemia
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1114 Paediatrics and Reproductive Medicine
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: Symplectic Elements
Date Deposited: 22 Nov 2016 02:15
Last Modified: 29 Nov 2016 02:51
URI: http://vuir.vu.edu.au/id/eprint/32133
DOI: https://doi.org/10.1186/s12929-016-0233-8
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Citations in Scopus: 2 - View on Scopus

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