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GFP expression alters osteosarcoma cell biology

Dass, Crispin R and Choong, Peter F. M (2007) GFP expression alters osteosarcoma cell biology. DNA Cell Biology, 26 (8). pp. 599-601. ISSN 1044-5498

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Abstract

Green fluorescent protein (GFP) expression is widely used for tracking of cells in vivo. Three human osteosarcoma cell lines were transfected with GFP and analyzed for expression of tissue markers and physiology. GFP-mediated increased tumor aggression in vivo in one cell line was corroborated by altered expression of bone markers and osteoblast-like cell biology in vitro as a result of transfection. The use of GFP for cell tracking in osteosarcoma animal models should therefore be used with caution.

Item Type: Article
Uncontrolled Keywords: ResPubID18876, green fluorescent protein (GFP), cells in vivo, human osteosarcoma cell lines, tumor aggression, bone markers, cell tracking
Subjects: FOR Classification > 1112 Oncology and Carcinogenesis
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
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Depositing User: VUIR
Date Deposited: 08 May 2012 02:10
Last Modified: 09 May 2012 06:49
URI: http://vuir.vu.edu.au/id/eprint/3228
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Citations in Scopus: 9 - View on Scopus

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