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Non-viral methods for gene transfer towards osteosarcoma therapy

Dass, Crispin R and Choong, Peter F. M (2007) Non-viral methods for gene transfer towards osteosarcoma therapy. Journal of Drug Targeting, 15 (3). pp. 184-189. ISSN 1061-186X

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Abstract

Osteosarcoma, a class of cancer that originates from bone, afflicts mainly young people usually in their teenage years of life. Despite surgery and chemotherapy, the outlook for sufferers is not that positive, with a third of patients with metastatic disease not surviving past the 10-year mark. Like other neoplasms, other forms of therapeutics are being evaluated, and amongst these is gene therapy. This review discusses approaches for gene therapy of osteosarcoma using cationic liposomes and polyethylenimine in vivo. The field is still in its infancy as far as osteosarcoma is concerned and much more needs to be done to test its true potential as a feasible therapeutic modality.

Item Type: Article
Uncontrolled Keywords: ResPubID18877, Gene therapy, osteosarcoma, non-viral, cancer, antisense
Subjects: FOR Classification > 1112 Oncology and Carcinogenesis
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
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Depositing User: VUIR
Date Deposited: 04 May 2012 03:38
Last Modified: 09 May 2012 06:48
URI: http://vuir.vu.edu.au/id/eprint/3229
DOI: 10.1080/10611860701231547
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Citations in Scopus: 1 - View on Scopus

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