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The Effects of Dietary Supplements on Skeletal Muscle Function in Type 2 Diabetic Rats

Pompeani, Nancy (2016) The Effects of Dietary Supplements on Skeletal Muscle Function in Type 2 Diabetic Rats. PhD thesis, Victoria University.

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Abstract

Type 2 Diabetes is considered to be a heterogeneous disease, and whilst its pathogenesis is currently unknown, it is often characterized by high plasma free fatty acids (FFAs), hyperglycaemia, and altered insulin secretion from pancreatic β-cells. Whilst multiple organ systems are often affected by the disease, the effects on skeletal muscle in particular are pertinent, as this is the main organ responsible for glucose disposal, and also has a major role in basal and altered metabolism. The overall aim of this thesis is to examine the extent of any changes to skeletal muscle morphology and (dys)function in Type 2 Diabetes and how these can be improved by the use of dietary supplements. Specifically, the potential of Creatine Monohydrate, Whey Protein Isolate, and Aspirin on the contractile apparatus and specific intramyocellular organelles will be tested in order to reverse some of the maladaptations found in skeletal muscle of Type 2 Diabetic patients.

Item Type: Thesis (PhD thesis)
Uncontrolled Keywords: skeletal muscles, muscle atrophy, muscle function, therapies, supplementation, fatigue, metabolites, metabolism
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1106 Human Movement and Sports Science
FOR Classification > 1111 Nutrition and Dietetics
Faculty/School/Research Centre/Department > College of Health and Biomedicine
Depositing User: VU Library
Date Deposited: 12 Dec 2016 03:55
Last Modified: 12 Dec 2016 03:55
URI: http://vuir.vu.edu.au/id/eprint/32315
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