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Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy
Timpani, Cara (2017) Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy. PhD thesis, Victoria University.
Full text for this resource is not available from the Research Repository.Abstract
Duchenne Muscular Dystrophy (DMD) is a fatal skeletal muscle wasting disease underpinned by extensive metabolic dysfunction. This culminates in reduced energy production which is detrimental to dystrophic muscle since buffering damage and stimulating repair are energy dependent processes. Current treatment options for DMD are limited and do not address this metabolic dysfunction despite the extensive role it plays in DMD pathogenesis and disease progression. Therefore, this thesis investigated the efficacy of two metabolic therapies, sodium nitrate and adenylosuccinic acid (ASA), to improve skeletal muscle metabolism and architecture in the well-established mdx mouse model of DMD, and in immortalised myoblasts derived from DMD patients.
Item Type: | Thesis (PhD thesis) |
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Additional Information: | Full-text unavailable due to Copyright restrictions |
Uncontrolled Keywords: | neuromuscular diseases, muscle wasting, DMD, metabolism, metabolic system, metabogenic therapy, ASA therapy, treatment, mice, mitochondrial, histopathology, nitrate supplementation, nitrite supplementation, supplements, adenylosuccinic acid |
Subjects: | FOR Classification > 1101 Medical Biochemistry and Metabolomics FOR Classification > 1109 Neurosciences Faculty/School/Research Centre/Department > College of Health and Biomedicine |
Depositing User: | VU Library |
Date Deposited: | 14 Jul 2017 04:44 |
Last Modified: | 14 Jul 2017 04:44 |
URI: | http://vuir.vu.edu.au/id/eprint/34336 |
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