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Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone- resorbing activity and apoptosis pathway

Akiyama, Toru and Dass, Crispin R and Choong, Peter F. M (2008) Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone- resorbing activity and apoptosis pathway. Molecular Cancer Therapeutics, 7 (11). pp. 3461-3469. ISSN 15357163

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Abstract

Osteosarcoma is the most common bone sarcoma, which mainly affects adolescents and young adults. Although the combination of modern surgery and systemic chemotherapy has improved osteosarcoma treatment dramatically, no substantial change in survival has been seen over the past 20 years. Therefore, novel therapeutic strategies for osteosarcoma are required if the 35% of patients with fatal metastases are to be successfully treated. Recently, osteoclasts have drawn attention as a therapeutic target in various bone disorders including osteosarcoma. The osteoclast is the sole cell that resorbs bone and is central in pathologic situations, where bone destruction is intricately involved. Osteosarcoma cells are of the osteoblastic lineage, the latter of which is characterized by cells secreting the osteoclast-inducing factor, receptor activator of nuclear factor-KB ligand. Hence, osteosarcoma is a better candidate for osteoclast-targeted therapy than other primary and metastatic bone tumors. The rapid progress on the molecular mechanism regulating osteoclast has propelled a development of new therapeutic approaches. In this review article, we present the prospects of osteoclast-targeted therapy as a novel treatment strategy for osteosarcoma. Receptor activator of nuclear factor-KB-Fc, osteoprotegerin, bisphosphonates, and Src inhibitor are shown as positive candidates and can control various aspects of osteoclast function.

Item Type: Article
Uncontrolled Keywords: ResPubID18869. osteosarcoma, bone sarcoma, multidisciplinary therapy, malignant tumor of bone
Subjects: FOR Classification > 1199 Other Medical and Health Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Depositing User: VUIR
Date Deposited: 11 Aug 2011 05:19
Last Modified: 23 Jan 2015 02:50
URI: http://vuir.vu.edu.au/id/eprint/3466
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Citations in Scopus: 41 - View on Scopus

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