Understanding the role of MasR in vascular pathology
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Rai, Sudarshan (2016) Understanding the role of MasR in vascular pathology. Research Master thesis, Victoria University.
Abstract
Homocysteine was first suggested as a risk to CVD in 1969. Since then, elevated plasma homocysteine (derived from methionine) has remained a cardiovascular risk factor with no current treatment. Homocysteine is known to stimulate NADPH oxidase, and NADPH oxidase can be inhibited by stimulation of the Mas receptor (MasR) of the renin angiotensin system. Stimulation of MasR is known to reduce organ fibrosis through the production of NO. However, the role that MasR plays in homocysteine-induced vascular pathology, including endothelial dysfunction and organ fibrosis, is not known. The aim of this thesis is to determine if high methionine diet in MasR-/- mice will worsen cardiovascular pathology.
| Additional Information | Master of Science (Research) |
| Item type | Thesis (Research Master thesis) |
| URI | https://vuir.vu.edu.au/id/eprint/35026 |
| Subjects | Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics Historical > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology Current > Division/Research > College of Health and Biomedicine |
| Keywords | cardiovascular disease, CVD, endothelial function, myocardial fibrosis, immunochemistry, renal disease, risk factors, receptors |
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